Mario Balotelli, Stephan El Shaarawy and Kevin-Prince Boateng lead Milan’s attack in the Champions League play-off with PSV.
The first leg kicks off in Eindhoven at 19.45 UK time (18.45 GMT) with the return match at San Siro on August 28.
Balotelli has shaken off a knee problem that ruled him out of Italy’s friendly with Argentina last week, so is fit to partner El Shaarawy and Boateng.
Robinho, Mattia De Sciglio, Jherson Vergara, Gabriel and Luca Antonini are unavailable due to injury.
Nigel De Jong has impressed in pre-season after recovering from a torn Achilles tendon and starts in midfield with fellow Dutch international Urby Emanuelson.
PSV Eindhoven’s season has already started and they have won all five of their competitive games so far in 2013-14.
Luciano Narsingh is a long-term absentee, while Park Ji-Sung and Zakaria Bakkali required fitness tests, but only the Korean is able to play.
The last time these sides met was in the Champions League quarter-final, when Milan progressed on away goals after Massimo Ambrosini’s stoppage-time strike in a 3-1 Eindhoven defeat.
PSV’s current Coach, Phillip Cocu, was in the line-up that day and bagged a brace.
The most dangerous goal threats this time around are former Napoli transfer target Tim Matavz and 19-year-old Dutch talent Memphis Depay.
The referee is Cuneyt Cakir, the Turkish official who famously sent off Nani for Manchester United against Real Madrid last season.
PSV: Zoet; Brenet, Bruma, Rekik, Willems; Schaars, Maher; Park, Wijnaldum, Depay; Matavz
PSV bench: Tyton, Jorgensen, Arias, Hiljemark, Toivonen, Locadia, Jozefzoon
Milan: Abbiati; Abate, Mexes, Zapata, Emanuelson; Montolivo, De Jong, Muntari; Boateng, Balotelli, El Shaarawy
Milan bench: Amelia, Constant, Zaccardo, Nocerino, Poli, Niang, Petagna
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more