Jeremy Menez and Francesco Totti complete an attacking line-up as Roma take on Mauro Zarate's Lazio in the Derby della Capitale.
The big game of this afternoon is the battle for Roman supremacy and Vincenzo Montella's first edition as Coach.
He has chosen captain Totti in the starting XI after dropping him midweek at Shakhtar Donetsk, joining Menez, Simone Perrotta and Mirko Vucinic in a 4-2-3-1 system.
Daniele De Rossi is also included despite his recent disciplinary problems and John Arne Riise keeps his spot at left-back, while Nicolas Burdisso moves to the right.
Matteo Brighi and Aleandro Rossi are suspended with Marco Cassetti sidelined.
Lazio have a similar system with Sergio Floccari leading the line supported by Giuseppe Sculli, Hernanes and Mauro Zarate.
Stephan Lichtsteiner has recovered to start in defence, but Andre Dias failed a fitness test and is out with Tommaso Rocchi and Mobido Diakitè.
Roma: Doni; N Burdisso, Juan, Mexes, Riise; Pizarro, De Rossi; Menez, Perrotta, Vucinic; Totti
Lazio: Muslera; Lichtsteiner, Stendardo, Biava, Radu; Ledesma, Matuzalem; Sculli, Hernanes, Zarate; Floccari
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more