Can Milan get their first points of the campaign with Alessandro Matri against Cagliari? Inter face a tricky Catania trip and Roma challenge giant-killers Verona.
The action begins today at 17.00 UK time with Verona seeking another shock scalp at the Olimpico.
Matri could make his Milan debut against old club Cagliari, while Genoa-Fiorentina, Catania-Inter and Udinese-Parma have the potential for upsets.
Atalanta-Torino, Bologna-Sampdoria and Sassuolo-Livorno are early relegation dogfights that could prove decisive come the end of the season.