Bad news for Juventus, as Martin Caceres has a suspected torn meniscus while on international duty.
The Uruguay medical staff released a statement confirming he will not take part in the game against Colombia due to this knee injury.
Defender Caceres sustained the setback during a World Cup qualifier with Peru earlier this week.
He will now fly back to Italy in order to undergo further tests and decide on a course of action.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!