After Fiorentina host Cagliari in a bid to join Napoli on top of the table, Lazio face their bête noir and it’s a fiery Derby della Lanterna.
Click here for previews of every single Serie A Week 3 match , plus reports on Saturday’s Inter-Juventus, Torino-Milan and Napoli-Atalanta.
The action begins at 11.30am UK time at the Stadio Artemio Franchi, where Fiorentina aim to keep their 100 per cent record against Cagliari.
In the afternoon Lazio take on Chievo, a side they haven’t been able to beat in Rome since 2003, plus have to do without the suspended Hernanes.
Antonio Di Natale marks his 300th Serie A game in an Udinese jersey.
This evening the bizarre spy stories and camouflage kits  are swept aside, as Genoa and Sampdoria face off in a bitter local derby.
Week 3 is concluded on Sunday night with Parma-Roma, as Antonio Cassano takes on Francesco Totti.