Napoli go on the attack with Borussia Dortmund, as Gonzalo Higuain and Jose Maria Callejon face Robert Lewandowski.
The campaign kicks off at the Stadio San Paolo this evening at 19.45 UK time (18.45 GMT) while also in this group Arsenal visit Olympique Marseille.
Rafa Benitez has a great history in European competition and so do new players like Gonzalo Higuain and Jose Maria Callejon.
They both start tonight along with Marek Hamsik and Lorenzo Insigne, as the Coach has promised to attack the Germans.
Borussia Dortmund lost last season’s Champions League Final to Bayern Munich and are currently top of the Bundesliga after thrashing Hamburg 6-2 on Saturday.
Jurgen Klopp has to do without the injured Ilkay Gundogan, Sebastian Kehl and Lukasz Piszczek, but there is a huge surprise.
Jakub Blaszczykowski was not 100 per cent fit leading up to the game, but has surprisingly been chosen ahead of Pierre-Emerick Aubameyang.
Jurgen Klopp said playing at the San Paolo “will be a mystical experience.”
Napoli: Reina; Maggio, Albiol, Britos, Zuniga; Inler, Behrami; Callejon, Hamsik, Insigne; Higuain
Napoli bench: Rafael, Cannavaro, Armero, Dzemaili, Pandev, Mertens, Mesto
Borussia Dortmund: Weidenfeller; Schmelzer, Subotić, Hummels, Grosskreutz; Şahin, Bender; Reus, Mkhitaryan, Blaszczykowski; Lewandowski
Borussia Dortmund bench: Langerak, Kirch, Aubameyang, Gunter, Hofmann, Schieber, Durm