Fiorentina rely on Giuseppe Rossi, Borja Valero and Joaquin in their Europa League opener against Pacos Ferreira.
Their continental campaign begins in earnest at the Stadio Artemio Franchi at 18.00 UK time (17.00 GMT).
Coach Vincenzo Montella has some reshuffling to do, as Mario Gomez and Juan Guillermo Cuadrado are both out for several weeks.
Rossi therefore starts with summer signing Joaquin and Borja Valero in a trequartista role, while David Pizarro plays because he must sit out a two-match Serie A ban.
Marcos Alonso receives his first start in a Viola jersey in defence, but Oleksandar Iakovenko is only fit enough for the bench.
Alberto Aquilani, Manuel Pasqual and Facundo Roncaglia are also rested.
Pacos Ferreira are a Portuguese club who entered the Europa League after losing the Champions League play-offs 8-3 on aggregate to Luciano Spalletti’s Zenit.
This is only their third ever season in Europe and their unofficial Coach is former Atalanta midfielder Costinha.
Fiorentina: Neto; Tomovic, Gonzalo Rodriguez, Compper, Alonso; Ambrosini, Pizarro, Fernandez; Borja Valero; Joaquin, Rossi
Fiorentina bench: Munua, Roncaglia, Pasqual, Bakic, Aquilani, Iakovenko, Ryder
Pacos Ferreira: Degra; Tony, Filipe Anunciacao, Ricardo, Nuno Santos; Hurtado, Andre Leao, Seri, Ruben Ribeiro; Bebe, Irobiso
Pacos Ferreira: Filipe, Gregory, Romeu, Rui Miguel, Rodrigo Antonio, Caetano, Manuel Jose