The day begins with the Derby della Mole early kick-off, then Inter take on Cagliari and Sassuolo-Lazio before Roma-Bologna and Monday’s Fiorentina-Parma.
Click here for match previews on every single Serie A Week 6 fixture , plus reports from Saturday’s Genoa-Napoli and Milan-Sampdoria.
Set your clocks for the Turin Derby at 11.30am UK time (10.30 GMT), when Torino look for their first win over Juventus since 1995.
This afternoon several big clubs face tricky tests, as Inter visit Cagliari in Trieste, Lazio take on a revived Sassuolo and Verona-Livorno is a clash of two newly promoted sides with excellent starts to the season.
The evening kick-off has Roma defending their historic perfect record against Bologna, then Fiorentina-Parma rounds out the long weekend on Monday night.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!