Lazio give two new signings their debuts amid an injury crisis in a tricky Europa League trip to Trabzonspor.
Both sides won their opening games, so this is a head-to-head for leadership of Group J and kicks off at 18.00 UK time (17.00 GMT).
Coach Vladimir Petkovic insisted they were going to Turkey in order to win despite the long list of absentees.
Lazio must do without Miroslav Klose, Giuseppe Biava, Andre Dias, Abdoulay Konko, Diego Novaretti, Bruno Pereirinha and Stefano Mauri.
Colombian 20-year-old striker Brayan Perea therefore gets his first start in an Aquile jersey, supported by Hernanes, Antonio Candreva and newcomer Felipe Anderson, a 20-year-old Brazilian who makes his debut (pictured).
This is not Petkovic’s first time in Turkey, as he had a six-month spell in charge of Samsunspor in 2011-12.
Trabzonspor have a few star names in their ranks, including Florent Malouda, Bosingwa and Paulo Henrique.
Aydogdu is out injured, but Trabzonspor have won their last four in a row in all competitions.
Trabzonspor: Onur Kivrak; Bosingwa, Aykut Demir, Mustafa Yumlu, Olcan Adin; Zokora, Colman; Yusuf Erdogan, Mierzejewski, Malouda; Paulo Henrique
Trabzonspor bench: Zeki Ayvaz, Bamba, Giray Kacar, Aykut Akgun, Abdulkadir Ozdemir, Alanzinho, Janko
Lazio: Marchetti; Cavanda, Ciani, Cana, Lulic; Hernanes, Biglia; Candreva, Onazi, Felipe Anderson; Perea
Lazio bench: Berisha, Serpieri, Ederson, Gonzalez, Ledesma, Keita Balde, Floccari