A decimated Lazio need to get back on track against Cesena and have completely revamped the defence and midfield.
Edy Reja's men need a result to make up for the Rome derby defeat and fight back for fourth place.
There are precious few options, though, as Stefan Radu, Cristian Ledesma and Stephan Lichtsteiner are all suspended.
They join the injured Sergio Floccari, Tommaso Rocchi, Mobido Diakitè, Cristian Brocchi and Mark Bresciano.
Stefano Mauri and Andre Dias return, supporting strikers Mauro Zarate and Giuseppe Sculli, while Lionel Scaloni and Javier Garrido complete a revamped defence.
Cesena are missing the suspended Emanuele Giaccherini, while Alessandro Rosina, Paolo Sammarco, Dias Felipe, Ivan Fatic and centre-forward Igor Budan are sidelined.
Dominique Malonga won the race to start in attack, leading Erjon Bogdani and Luis Jimenez.
Lazio: 86 Muslera; 5 Scaloni, 20 Biava, 3 Dias, 14 Garrido; 15 Gonzalez, 11 Matuzalem, 6 Mauri; 8 Hernanes; 10 Zarate, 77 Sculli
Lazio bench: 12 Berni, 13 Stendardo, 31 Meghni, 81 Del Nero, 32 Brocchi, 92 Ceccarelli, 18 Kozak
Cesena: 1 Antonioli; 46 Santon, 3 Pellegrino, 25 Von Bergen, 6 Lauro; 8 Caserta, 14 Colucci, 18 Parolo; 10 Jimenez; 71 Bogdani, 17 Malonga
Cesena bench: 33 Calderoni, 15 Benalouane, 19 Gorobsov, 4 Appiah, 77 Ceccarelli, 44 Piangerelli, 7 Riski
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!