Dani Osvaldo, Lorenzo Insigne and Andrea Pirlo start as Italy play their final 2014 World Cup qualifier against Armenia.
It kicks off at the Stadio San Paolo in Naples at 19.45 UK time (18.45 GMT).
The Azzurri have already qualified, but a victory would guarantee their spot as top seeds in the Finals draw.
Armenia are locked in a battle for second place in Group B, but it’s likely whoever finishes runner-up still won’t have enough points to make it into the play-offs.
Bulgaria and Denmark have 13 points each, followed by the Czech Republic and Armenia on 12.
Mario Balotelli is not ready to start after suffering from gastroenteritis last week, but Napoli star Insigne plays in his hometown stadium alongside Southampton striker Osvaldo and Roma’s Alessandro Florenzi.
Fiorentina striker Giuseppe Rossi is expected to come on for the second half. He has not worn the Azzurri jersey since a 1-1 draw in Serbia on October 7 2011, followed by an injury nightmare.
Daniele De Rossi is out injured and Gigi Buffon is rested, so Alberto Aquilani and Federico Marchetti step in.
Cesare Prandelli continues his experiments in defence with Cagliari’s Davide Astori and Fiorentina captain Manuel Pasqual.
The only previous meeting between these nations was the qualifier last year when Italy won 3-1 in Armenia.
Italy: Marchetti; Abate, Astori, Bonucci, Pasqual; Pirlo; Florenzi, Aquilani, Montolivo, Insigne; Osvaldo
Italy bench: Buffon, Chiellini, Thiago Motta, Balzaretti, Candreva, Balotelli, Cerci, Sirigu, De Silvestri, Rossi, Giaccherini, Verratti
Armenia: Berezovski; Arzumanyan, Hayrapetyan, Mkoyan, Haroyan; Mkrtchyan, Ozbiliz, Ghazaryan, Mkhitaryan; Yedigaryan, Movsisyan
Armenia bench: Pinheiro, Malakyan, Sarkisov, Kasparov, Hovhannnisyan, Aleksanyan, Avagyan, Manoyan, Dashyan