Fiorentina-Juventus is always a fiery occasion, while today also brings Atalanta-Lazio, Torino-Inter and an Emilia-Romagna Derby.
Click here for individual match previews of every single Serie A Week 8 encounter , plus reports from Roma-Napoli, Cagliari-Catania and Milan-Udinese.
The action begins at 11.30am UK time (10.30 GMT) with Lazio aiming to end their travelling curse against Atalanta.
This afternoon Fiorentina-Juventus is one of Serie A’s most keenly-felt grudge matches, while Gian Piero Gasperini makes his Marassi comeback in Genoa-Chievo.
Sassuolo-Bologna is an Emilia-Romagna Derby, with Livorno-Sampdoria and Verona-Parma relegation dogfights.
This evening Inter visit Torino for their first match under new owner Erick Thohir.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!