Napoli need to get their Champions League campaign back on track away to Olympique Marseille and start Gonzalo Higuain.
This Group F game kicks off at the Stade Velodrome at 19.45 UK time (18.45 GMT).
The Partenopei won their opening tie 2-1 over Borussia Dortmund, but lost 2-0 at Arsenal, so need to improve their away record.
Higuain has not started the last three games, but has finally shaken off his muscular problem to line up alongside Dries Mertens, Marek Hamsik and Jose Maria Callejon. Lorenzo Insigne is rested.
Juan Camilo Zuniga and Miguel Angel Britos are unavailable after knee surgery and a dislocated shoulder.
Olympique Marseille already feel like they are at the Last Chance Saloon after two consecutive defeats, scoring one goal and conceding five.
There are problems for Coach Elie Baup, who has to do without the injured Lucas Mendes and Saber Khalifa.
Andre-Pierre Gignac is supported by Mathieu Valbuena and Andre Ayew, but their defence is the weak link.
This is the first time the two sides have faced each other. There was trouble in the build-up to the game, as a bus carrying Napoli supporters was pelted with rocks and had windows smashed.
Olympique Marseille: Mandanda; Fanni, Diawara, N'Koulou, Morel; Romao, Cheyrou; Payet, Valbuena, A Ayew; Gignac
Marseille bench: Samba, Abdallah, B Mendy, Lemina, Imbula, Thauvin, J Ayew
Napoli: Reina; Maggio, Albiol, Fernandez, Armero; Behrami, Inler; Mertens, Hamsik, Callejon; Higuain
Napoli bench: Rafael, Cannavaro, Mesto, Dzemaili, Insigne, Pandev, Zapata
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!