Juventus have Carlos Tevez and Andrea Pirlo against Cristiano Ronaldo and Gareth Bale of Real Madrid.
This Champions League showdown kicks off in Turin at 19.45 GMT and is a must-win for the Bianconeri, who have only two points from three games.
The 2-1 defeat at the Bernabeu was controversial, as it saw Giorgio Chiellini sent off for a seemingly innocuous shoulder-to-shoulder with Ronaldo.
As a result, the veteran defender is suspended this evening, while Stephan Lichtsteiner and Mirko Vucinic are still unavailable due to injury.
Kwadwo Asamoah is given the task of stopping Bale, preferred at left-back to Angelo Ogbonna despite being technically a wide midfielder.
Once again, Antonio Conte switches his usual 3-5-2 system to a 4-3-3 in order to match Carlo Ancelotti’s side.
Claudio Marchisio is pushed into a more advanced role with Fernando Llorente and Tevez.
Real Madrid have a 100 per cent record in Group B so far, but are without Fabio Coentrao after he sprained his ankle in a 3-2 win at Rayo Vallecano.
Raul Arbeloa is dropped, as Sergio Ramos is re-routed to right-back.
The Spaniards have a poor history away to Juventus, losing their last five trips to Turin on the bounce.
Their most recent visit was 2-1 in October 2008, secured by Alessandro Del Piero and Amauri.
Conte called for the Juventus Stadium to be turned into “a cauldron” and an hour before kick-off that already seems to be the case.
Juventus: Buffon; Caceres, Barzagli, Bonucci, Asamoah; Vidal, Pirlo, Pogba; Tevez, Llorente, Marchisio
Juventus bench: Storari, Ogbonna, De Ceglie, Padoin, Isla, Giovinco, Quagliarella
Real Madrid: Casillas; Ramos, Varane, Pepe, Marcelo; Khedira, Xabi Alonso, Modric; Bale, Benzema, Cristiano Ronaldo
Real Madrid bench: Diego Lopez, Carvajal, Arbeloa, Jesé, Di Maria, Isco, Illarra