Milan in crisis visit bottom of the table Chievo and hope Alessandro Matri can help them to their first away win.
It kicks off at the Stadio Bentegodi in Verona at 14.00 GMT, click here for a match preview .
The Rossoneri are in dire straits after back-to-back defeats against Fiorentina and Barcelona, while in Serie A alone they have one point from three rounds.
Mario Balotelli is suspended due to an accumulation of yellow cards, joining the injured Stephan El Shaarawy, Mattia De Sciglio, Giampaolo Pazzini and Matias Silvestre.
Matri therefore starts with support from Kaka in a more traditional 4-4-2, while Urby Emanuelson is preferred to Kevin Constant.
Philippe Mexes returns after his four-match ban to shore up the defence.
Chievo are in even worse condition, propping up the Serie A table with last week’s draw at Bologna ending a run of six consecutive defeats.
Simone Bentivoglio and Claiton Dos Santos are out of action, but Cyril Thereau has shaken off an injury.
It’s a special game for Alberto Paloschi, who is at Chievo on loan from Milan.
History does not smile on the Flying Donkeys in this Serie A fixture, as they have only ever beaten Milan twice – home and away – with three draws and 17 defeats.
Chievo: Puggioni; Frey, Dainelli, Cesar; Sardo, Radovanovic, L.Rigoni, Pamic, Estigarribia; Paloschi, Pellissier
Chievo bench: Silvestri, Squizzi, Bernardini, Papp, Hetemaj, Dramè, Sestu, Improta, Acosty, Lazarevic, Ardemagni, Thereau
Milan: Abbiati; Abate, Zapata, Mexes, Emanuelson; Poli, Montolivo, De Jong, Muntari; Kaka; Matri
Milan bench: Amelia, Gabriel, Bonera, Zaccardo, Cristante, Constant, Birsa, Niang, Robinho
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's World Cup tipster competition  - £10,000 to be won!