Juventus can temporarily take the top spot with a result away to Livorno, while Sinisa Mihajlovic makes his Sampdoria debut against Lazio.
Click here for all the individual match previews from Serie A Week 13 , plus reports from Saturday’s games Milan-Genoa, Napoli-Parma and Verona-Chievo .
As Roma’s clash with Cagliari is played on Monday evening due to the Stadio Olimpico being used for rugby, Juventus have the opportunity to temporarily go top of the table, but have a decimated defence for their trip to Livorno.
Fiorentina can also close on the leaders against stuttering Udinese, while Inter challenge Alessandro Diamanti’s Bologna.
Sampdoria Coach Mihajlovic makes his debut against another of his former clubs, Lazio.
There are also some key relegation tussles in Sassuolo-Atalanta and Torino-Catania.
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!