Cristian Chivu has picked up a thigh injury on international duty, so Inter's defence is increasingly at risk for the derby.
The Nerazzurri are already without Walter Samuel and the suspended Lucio for the April 2 clash with Milan.
Andrea Ranocchia is unlikely to feature after leaving the Italy camp early and admitting he could require knee surgery.
Now news filters through from the Romania camp that Chivu has picked up a thigh injury on international duty.
Tests will be needed to ascertain the extent of the problem to his right thigh.
If Chivu is also ruled out, then the centre-backs against Milan could be Ivan Cordoba and veteran Marco Materazzi.