Roma’s unbeaten record is at risk against Vincenzo Montella’s Fiorentina in the early kick-off, while Antonio Cassano visits Inter.
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The action begins at 11.30 GMT at the Stadio Olimpico, as Roma try to end their run of four consecutive draws against high-flying Fiorentina.
This afternoon Lazio hope to end their crisis away to Torino, Sinisa Mihajlovic’s Sampdoria host his former club Catania, Cagliari welcome Genoa plus relegation battles Sassuolo-Chievo and Verona-Atalanta.
At 19.45 GMT Cassano returns to San Siro with his giant-killing Parma teammates against Inter.