There are some huge battles, including Napoli-Inter and Milan-Roma, while Sassuolo test Juventus and Fiorentina play the Derby dell’Appennino.
Click here for match previews of every single Serie A Week 16 match , plus the report from Saturday’s Catania-Verona.
It all begins this afternoon with Fiorentina hosting Bologna, Parma celebrate their Centenary against Cagliari and Lazio-Livorno is always a very fiery occasion.
Chievo-Sampdoria is a duel between two teams revived by new Coaches, while Genoa-Atalanta and Udinese-Torino are mid-table tussles.
Juventus-Sassuolo has been moved to 17.30 GMT thanks to the Bianconeri’s extended stay under the snow in Istanbul this week.
This evening there is a massive blast from the past, as Walter Mazzarri returns to the San Paolo for the first time as an opponent against ex-Inter Coach Rafa Benitez’s Napoli.
The round concludes on Monday when Milan welcome still-unbeaten Roma on Francesco Totti’s comeback.