Fiorentina go for a new all-attack approach against Cesena with Alessio Cerci, Adrian Mutu, Juan Manuel Vargas and Alberto Gilardino together.
Coach Sinisa Mihajlovic has also included Mario Alberto Santana, who moves from winger to deep-lying midfielder in the role vacated by the injured Riccardo Montolivo.
The Viola need a victory at the Stadio Artemio Franchi in the 17.00 UK time kick-off, but Lorenzo De Silvestri is dropped to the bench and Cesare Natali failed a fitness test.
Cesena stick largely with the side that defeated Lazio midweek, so Luis Jimenez and Emanuele Giaccherini support Erjon Bogdani.
There are some changes, as Ezequiel Schelotto steps in for Stephen Appiah.
Fiorentina: Boruc; Comotto, Gamberini, Kroldrup, Pasqual; Santana, Donadel; Cerci, Mutu, Vargas; Gilardino
Fiorentina bench: Avramov, De Silvestri, Gulan, D'Agostino, Bolatti, Marchionni, Ljajic
Cesena: Antonioli; Lauro, Benalouane, Von Bergen, Nagatomo; Schelotto, Colucci, Parolo; Jimenez, Giaccherini; Bogdani
Cesena bench: Cavalieri, Pellegrino, Appiah, Fatic, Ighalo, Piangerelli, Cerccarelli
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £5,000 monthly.