Inter and Milan are desperate for points against Catania and Cagliari, while Roma visit Verona and Fiorentina-Genoa is the late kick-off to close on top spots.
Click here for individual match previews of every single Serie A Week 21 game , plus reports for Saturday’s surprise outcomes Napoli-Chievo and Lazio-Juventus.
The action begins at the Stadio Bentegodi at 11.30 GMT with high-flying Verona hosting second-placed Roma, as Luca Toni faces his former club eager to cause an upset.
As Juve’s run of 12 consecutive victories came to a halt last night, a win would put the Giallorossi only six points adrift of the leaders.
Milan have had conflicting results under Clarence Seedorf and he has his first away game in Sardinia, while Inter simply cannot afford to drop more points against bottom of the table Catania.
Livorno-Sassuolo is a desperate relegation dogfight on Mimmo Di Carlo’s debut, while Parma-Udinese, Sampdoria-Bologna and Torino-Atalanta are also intriguing.
The 19.45 GMT kick-off has Fiorentina aiming to make the most of any slip-ups to close on the Champions League spots, but amid an injury crisis they host a Genoa side fresh from beating Inter.