Lazio make changes against Bulgarian surprise package Ludogorets, as both teams are unbeaten in this Europa League.
The first leg of their Round of 32 encounter kicks off at 20.05 GMT at the Stadio Olimpico.
Vladimir Petkovic was in charge when the Biancocelesti qualified second in their group, but now Edy Reja is at the helm.
He suffered just two defeats since taking over, one in the Coppa Italia and another in Serie A at the weekend against Catania.
Ederson, Bruno Pereirinha and Helder Postiga are unavailable, but Miroslav Klose surprisingly starts.
Reja switches to a 3-4-3 system with Felipe Anderson and Keita Balde.
Lazio have lost at home to a Bulgarian side before, falling 1-0 to Levski Sofia in the 2009-10 Europa League group phase.
Ludogorets are the first Bulgarians to reach the Round of 32 in this tournament. They are without Vitinha and Burgzorg, who are not on the UEFA list.
Lazio: Berisha; Ciani, Cana, Radu; Cavanda, Onazi, Biglia, Lulic; Felipe Anderson, Klose, Keita
Lazio bench: Marchetti; Novaretti, Ledesma, Gonzalez, Candreva, Kakuta, Perea
Ludogorets: Stoyanov; Junior Caicara, Mantyla, Moti, Minev; Dyakov, Zlatinski; Aleksandrov, Marcelinho, Misidjan; Bezjak
Ludogorets bench: Cvorovic, Barthe, Choco, Fabio Espinho, Juninho Quixada, Dani Abalo, Lumu