Domenico Berardi and Alessio Romagnoli are in the Italy Under-21 side to face Northern Ireland on March 5.
This is a qualifier for the European Under-21 Championships and will be played in Lurgan on Tuesday at 16.00 GMT.
Sassuolo star Berardi is included after an impressive 12 Serie A goals so far this season, while Roma defender Romagnoli is a new face for Coach Gigi Di Biagio.
Bans rule out Sassuolo defender Luca Antei, Catania left-back Cristiano Biraghi and Atalanta midfielder Daniele Baselli.
Italy are currently third in their group behind Belgium and Serbia.
GK: Bardi (Livorno), Leali (Spezia), Perin (Genoa)
D: Bianchetti (Spezia), Ceccherini (Livorno), Chiosa (Bari), De Col (Virtus Lanciano), Murru (Cagliari), Romagnoli (Roma), Rugani (Empoli), Sabelli (Bari)
M: Battocchio (Watford), Benassi (Livorno), Cataldi (Crotone), Crisetig (Crotone), Dezi (Crotone), Molina (Modena), Viviani (Latina)
F: Belotti (Palermo), Berardi (Sassuolo), Bernardeschi (Crotone), Comi (Virtus Lanciano), Trotta (Brentford)
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