Juventus stick with the 4-3-3 system that conquered Roma as they welcome Genoa in the lunch-time game.
The 11.30 UK time kick-off sees the Bianconeri attempt to break back into the race for the Champions League spots.
It would be a third consecutive victory – something Gigi Del Neri's side have not achieved all season.
Gigi Buffon has still not recovered from the flu, so is replaced by Marco Storari between the posts.
Also absent are Giorgio Chiellini, Alessandro Del Piero, Vincenzo Iaquinta, Momo Sissoko, Leandro Rinaudo, Hasan Salihamidzic, Paolo De Ceglie and Fabio Quagliarella.
Fabio Grosso is suspended, so Armand Traoré and Marco Motta are the full-backs.
Juve stick with the new 4-3-3 system that worked against Roma last week, flanking Alessandro Matri with Milos Krasic and Simone Pepe.
In fact, the only change from the starting XI that beat the Giallorossi is the introduction of Traoré for Grosso.
Genoa need a boost after their embarrassing home defeat to Cagliari, which President Enrico Preziosi dubbed the “worst performance” of his entire reign.
Ex-Juve defender Domenico Criscito sits out a ban, while Miguel Veloso, Juraj Kucka, Mattia Destro and Rafinha haven't made the trip.
Rodrigo Palacio was also a major injury risk and is only fit for the bench, so Under-21 international Alberto Paloschi starts alongside Antonio Floro Flores.
Emiliano Moretti steps in for Criscito at left-back.
Juventus: Storari; Motta, Bonucci, Barzagli, Traoré; Aquilani, Felipe Melo, Marchisio; Krasic, Matri, Pepe
Juventus bench: Manninger, Sorensen, Grygera, Salihamidzic, Giandonato, Martinez, Toni.
Genoa: Eduardo; Mesto, Kaladze, Dainelli, Moretti; Rossi, Konko, Milanetto, Antonelli; Paloschi, Floro Flores
Genoa bench: Scarpi, Chico, Doninelli, Jankovic, Boselli, Jelenic, Palacio
Betting on Serie A? Bet365 are offering a 100% deposit bonus, up to £200 - find out more