Robinho, Alexandre Pato and Kevin-Prince Boateng start in Milan-Sampdoria, while Inter leave Wesley Sneijder on the bench at Parma.
With Zlatan Ibrahimovic suspended and injuries ruling out Alessandro Nesta, Massimo Ambrosini, Pippo Inzaghi, Daniele Bonera and Marek Jankulovski, the Serie A leaders return to the Brazilian pairing of Robinho and Pato.
Mario Yepes again replaces Nesta at centre-back, while Gennaro Gattuso is picked ahead of Mathieu Flamini in midfield.
Sampdoria are without Franco Semioli, Stefano Lucchini and the suspended Daniele Mannini.
Once again, Federico Macheda is benched in favour of Nicola Pozzi and Massimo Maccarone.
At the Stadio Tardini, Inter pay a visit to relegation strugglers Parma, but have chosen to leave out Douglas Maicon and Thiago Motta due to “a technical decision.”
Ivan Cordoba underwent knee surgery yesterday, so Yuto Nagatomo and Cristian Chivu complete the defence with Javier Zanetti advanced to midfield.
Still smarting from their Champions League exit to Schalke 04, the Nerazzurri have Giampaolo Pazzini available again and notably Esteban Cambiasso returns after he was surprisingly dropped in Gelsenkirchen.
Parma are without Raffaele Palladino and Fernando Marques, but Sebastian Giovinco and Antonio Candreva support Amauri in an ex-Juventus front three.
Hernan Crespo and Valeri Bojinov are on the bench.
Milan: Abbiati; Abate, Yepes, Thiago Silva, Zambrotta; Gattuso, Van Bommel, Seedorf; Boateng; Pato, Robinho
Sampdoria: Curci; Volta, Gastaldello, Martinez; Dessena, Tissone, Palombo, Koman, Laczko; Pozzi, Maccarone
Parma: Mirante; Zaccardo, Paletta, Lucarelli, Gobbi; Morrone, Dzemaili, Modesto; Candreva, Giovinco; Amauri
Inter: Julio Cesar; Nagatomo, Lucio, Ranocchia, Chivu; Zanetti, Cambiasso, Kharja; Stankovic; Pazzini, Eto'o