Zlatan Ibrahimovic returns to partner Antonio Cassano, as Milan welcome Palermo in the Coppa Italia semi-final.
The first leg kicks off at San Siro at 19.45 UK time and sees many injury problems for the Rossoneri.
Coach Max Allegri must do without Gianluca Zambrotta, Mario Yepes, Mark Van Bommel, Christian Abbiati, Massimo Ambrosini, Daniele Bonera, Pippo Inzaghi, Marek Jankulovski, Alessandro Nesta and Alexandre Pato.
Ibrahimovic is available because his three-match ban only applies to Serie A matches.
Andrea Pirlo also returns to the starting XI for the first time in two months with Marco Amelia, Massimo Oddo, Luca Antonini and Sokratis Papastathopoulos also stepping in.
Palermo have surprisingly left Fabrizio Miccoli on the bench, as he has an excellent scoring record against Milan.
Instead, Coach Delio Rossi has opted for Javier Pastore and Mauricio Pinilla supporting Abel Hernandez.
The Sicilians have fielded basically a full-strength squad, as the Coppa Italia is their only chance of silverware and best hope of qualifying for the Europa League.
Milan: 1 Amelia; 17 Oddo, 33 Thiago Silva, 15 Sokratis, 77 Antonini; 16 Flamini, 21 Pirlo, 10 Seedorf; 27 Boateng; 11 Ibrahimovic, 99 Cassano.
Milan bench: 30 Roma, 20 Abate, 66 Legrottaglie, 8 Gattuso, 28 Emanuelson, 51 Beretta, 70 Robinho
Palermo: 46 Sirigu; 16 Cassani, 3 Goian, 5 Bovo, 42 Balzaretti; 8 Migliaccio, 23 Nocerino, 94 Acquah; 27 Pastore; 51 Pinilla, 9 Hernandez
Palermo bench: 99 Benussi, 36 Darmian, 6 Munoz, 21 Bacinovic, 11 Liverani, 72 Ilicic, 10 Miccoli
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!