Roma-Juventus is a Serie A showcase with Mattia Destro, Gervinho and Francesco Totti against Carlos Tevez, Fernando Llorente and Andrea Pirlo.
It kicks off at 16.45 UK time (15.45 GMT), click here for a match preview .
Destro is back in the starting XI after his four-match ban and is eager to make the most of this spotlight to earn his place at the World Cup.
He is supported by Totti and Gervinho, while Miralem Pjanic starts to celebrate signing a new four-year contract.
Morgan De Sanctis is out after he suffered a bruised arm, while Alessio Romagnoli is suspended, so Skorupski starts in goal.
Juventus are without Arturo Vidal, Mirko Vucinic and Sebastian Giovinco, while Gigi Buffon is rested in favour of Marco Storari.
Tevez and Llorente lead the way with Pirlo and Paul Pogba in midfield, while Daniel Osvaldo is on the bench against his former club.
Roma: Skorupski; Torosidis, Benatia, Castan, Bastos; Nainggolan, De Rossi, Pjanic; Gervinho, Totti, Destro
Juventus: Storari; Barzagli, Bonucci, Chiellini; Lichtsteiner, Padoin, Pirlo, Pogba, Asamoah; Tevez, Llorente