Samuel Eto'o is back from his ankle injury as Inter face Mauro Zarate's Lazio in a head-to-head for third place.
This is a crucial battle for position, as in a few weeks the Nerazzurri have gone from Scudetto favourites to struggling to retain the third automatic Champions League qualifying spot.
Leonardo already raised his side's spirits with their 1-0 Coppa Italia semi-final win at Roma on Tuesday night, but had to do without Ivan Cordoba and Thiago Motta.
He dropped Douglas Maicon last week in the 2-0 defeat to Parma, but the Brazilian was back along with Wesley Sneijder and Diego Milito, again leaving Giampaolo Pazzini on the bench.
Lazio have had a remarkable campaign that isn't over yet, as they are both fighting to retain a top four finish and just three points adrift of Inter in third.
Francelino Matuzalem continues to sit out his lengthy ban for insulting the referee, while Giuseppe Sculli, Guglielmo Stendardo, Mobido Diakitè and Stephan Radu are all sidelined.
Christian Brocchi is not 100 per cent fit due to a muscular problem, so starts from the bench.
Zarate was dropped last week, but came off the bench to make such a huge impact that he has earned his place in the starting XI.
Inter: 1 Julio Cesar; 13 Maicon, 6 Lucio, 15 Ranocchia, 55 Nagatomo; 4 Zanetti, 19 Cambiasso, 5 Stankovic; 10 Sneijder; 22 Milito, 9 Eto'o.
Inter bench: 12 Castellazzi, 7 Pazzini, 17 Mariga, 20 Obi, 23 Materazzi, 26 Chivu, 27 Pandev
Lazio: 86 Muslera; 2 Lichtsteiner, 3 Dias, 20 Biava, 14 Garrido; 23 Bresciano, 24 Ledesma; 6 Mauri; 8 Hernanes; 10 Zarate, 22 Floccari
Lazio bench: 12 Berni, 5 Scaloni, 13 Stendardo, 15 Gonzalez, 18 Kozak, 19 Meghni, 32 Brocchi