Napoli bid to stay in the Scudetto race with Giuseppe Mascara and Edinson Cavani taking on Javier Pastore's Palermo.
The Partenopei shot themselves in the foot last week with a 2-1 home defeat to Udinese that left them six points adrift of leaders Milan.
Ezequiel Lavezzi and captain Paolo Cannavaro are suspended for this match, so ex-Catania star Mascara and former Lazio defender Emilson Sanchez Cribari step in.
Walter Gargano gets a rare midfield start in place of Hasan Yebda.
Palermo are without Fabrizio Miccoli, Mauricio Pinilla, Fabio Liverani and the suspended Dorin Goian.
Coach Delio Rossi has revived the team's confidence with a shock 3-2 win at Roma and 2-2 Coppa Italia semi-final draw away to Milan over the past week.
He goes for a 4-3-2-1 system with Pastore and Josip Ilicic supporting lone centre-forward Abel Hernandez.
Palermo: 46 Sirigu; 16 Cassani, 6 Munoz, 5 Bovo, 42 Balzaretti; 8 Migliaccio, 21 Bacinovic, 23 Nocerino; 27 Pastore, 72 Ilicic; 9 Hernandez
Palermo bench: 99 Benussi, 36 Darmian, 80 Carrozzieri, 29 Garcia, 94 Acquah, 77 Kurtic, 4 Kasami.
Napoli: 26 De Sanctis; 14 Campagnaro, 25 Cribari, 4 Ruiz; 11 Maggio, 5 Pazienza, 23 Gargano, 8 Dossena; 17 Hamsik, 9 Mascara; 7 Cavani
Napoli bench: 1 Iezzo, 6 Aronica, 13 Santacroce, 21 Yebda, 18 Zuniga, 77 Sosa, 99 Lucarelli
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!