Ezequiel Lavezzi is pushed up into a centre-forward role, while Thiago Motta is the trequartista in Napoli-Inter.
Tonight's 19.45 UK time kick-off at the San Paolo sees the Partenopei need just one point to ensure Champions League football.
Edinson Cavani and Giuseppe Mascara are both suspended, so Lavezzi has to move into a more advanced position with support from Marek Hamsik and the versatile Juan Zuniga.
Inter are defending second place and are without Wesley Sneijder, Dejan Stankovic, Lucio and Ivan Cordoba.
Marco Materazzi gets a rare start in central defence, leaving Cristian Chivu surprisingly on the bench, while Thiago Motta is pushed into the trequartista role.
Diego Milito and Samuel Eto'o are the strikers, so Giampaolo Pazzini is not included in the starting XI.
Napoli: 26 De Sanctis; 14 Campagnaro, 28 Cannavaro, 6 Aronica; 11 Maggio, 23 Gargano, 5 Pazienza, 8 Dossena; 18 Zuniga, 17 Hamsik; 22 Lavezzi
Napoli bench: 1 Iezzo, 3 Vitale, 4 Ruiz, 13 Santacroce, 21 Yebda, 77 Sosa, 99 Lucarelli
Inter: 1 Julio Cesar; 13 Maicon, 15 Ranocchia, 23 Materazzi, 55 Nagatomo; 4 Zanetti, 19 Cambiasso, 14 Kharja; 28 Thiago Motta; 22 Milito, 9 Eto'o
Inter bench: 12 Castellazzi, 7 Pazzini, 17 Mariga, 25 Samuel, 26 Chivu, 27 Pandev, 29 Coutinho