Piacenza were relegated to Lega Pro for the first time in 20 years after a dramatic 2-2 draw with Albinoleffe.
The sides were all square from the first leg and it looked as if Albinoleffe had it made when they went 2-0 up by half-time.
Girasole completed a well-worked free kick to open the scoring, then Grossi's left-foot strike doubled their advantage.
Piacenza fought back admirably after the break when Cacia both earned and converted a penalty.
Graffiedi completed the comeback by pouncing on a defensive error to make it 2-2.
However, away goals do not count in the Serie B play-offs, so with everything square after two legs it went down to the team with the superior record during the season.
Albinoleffe finished higher up the table, so they remain in Serie B and Piacenza go down to Lega Pro after two decades.
Albinoleffe 2-2 Piacenza
Scorers: Girasole 10 (A), Grossi 34 (A), Cacia pen 49 (P), Graffiedi 77 (P)
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £5,000 monthly.