Inter's must-win Champions League clash with Twente must rely on Wesley Sneijder and Samuel Eto'o with Marco Materazzi in defence.
Rafa Benitez is under immense pressure after losing two Serie A games on the trot and their last European outing against Tottenham.
Thiago Motta has recovered enough to start from the bench, but the Nerazzurri are missing Douglas Maicon, Julio Cesar, Coutinho, Cristian Chivu, Diego Milito, Joel Obi, Sulley Muntari and Walter Samuel.
Eto'o will sit out a three-match Serie A ban after head-butting Chievo's Bostjan Cesar in the chest, but is available for the Champions League.
Materazzi has to be drafted in to defence, while Ivan Cordoba gets the nod ahead of Davide Santon.
Twente welcome free kick specialist Theo Jansson back from his minor injury, while defender Rasmus Bengtsson has not recovered in time.
The result when these sides met in the first match was 2-2, but Twente are now just two points behind joint leaders Inter and Spurs.
Inter: Castellazzi; Cordoba, Lucio, Materazzi, Zanetti: Cambiasso, Stankovic; Biabiany, Sneijder, Pandev; Eto'o
Inter bench: Orlandoni, Natalino, Santon, Thiago Motta, Nwankwo, Biraghi, Crisetig
Twente: Mihaylov; Rosales, Douglas, Wisgerhof, Leugers; Brama, Janssen; Ruiz, De Jong, Chadli; Janko
Twente bench: Boschker, Landzaat, Schimpelsberger, Buysse, Parker, Vujicevic, John