Alessandro Del Piero takes over from the unwell Vincenzo Iaquinta to start against Fiorentina this evening.
This has always been one of the big grudge matches of Italian football and tonight's edition is expected to be no different.
Both sides are struggling with numerous injury problems that have rather forced the two tacticians into their line-up choices.
Juve are without Gigi Buffon, Nicola Legrottaglie, Leandro Rinaudo, Zdenek Grygera, Paolo De Ceglie, Jorge Martinez and Amauri.
Del Piero was expected to be rested, but had to come in after Vincenzo Iaquinta came down with a flu virus. Milos Krasic starts after his stunning comeback against Genoa last week.
Fiorentina miss out on Sebastien Frey, Riccardo Montolivo, Stevan Jovetic, Cristiano Zanetti, Adrian Mutu, Cesare Natali and the suspended Per Kroldrup.
With so few alternatives in defence, Sinisa Mihajlovic has had to field 18-year-old Michele Camporese at centre-back.
Mario Alberto Santana is preferred to former Juventus winger Marco Marchionni.
Juventus: Storari; Motta, Bonucci, Chiellini, Grosso; Krasic, Aquilani, Felipe Melo, Marchisio; Del Piero, Quagliarella
Juventus bench: Sissoko, Iaquinta, Traoré, Lanzafame, Pepe, Sorensen
Fiorentina: Boruc; Comotto, Camporese, Gamberini, Pasqual; Donadel, D'Agostino; Santana, Ljajic, Vargas; Gilardino
Fiorentina bench: Avramov, Babacar, Felipe, Cerci, Bolatti, De Silvestri, Marchionni
Think you know your Italian football? Share your knowledge, tips and comments to win cash prizes in OLBG's tipster competition  - £11,000 to be won monthly!