Milan are expected to test out a 3-5-2 system in the Europa League play-off against Shkendija with Leonardo Bonucci leading the defence.
It kicks off in Skopje on Thursday at 19.45 UK time (18.45 GMT), following on from the 6-0 first leg result at San Siro.
Coach Vincenzo Montella hinted he would use this opportunity to make some tactical changes and experiment with three at the back.
So far, the Rossoneri have played 4-3-3 or variations of it, but the moment Bonucci was signed from Juventus for €42m, there were inklings of a change in formation.
Alessio Romagnoli is back from injury and should start with Bonucci and Cristian Zapata.
There were likely to be big changes in midfield with youth team players Niccolo Zanellato and Manuel Locatelli, pushing Davide Calabria and Luca Antonelli in to more advanced roles.
Patrick Cutrone can therefore partner Andre Silva, as Nikola Kalinic completed his transfer from Fiorentina too late to be registered for this tie.
Milan (probable): Storari; Zapata, Bonucci, Romagnoli; Calabria, Zanellato, Locatelli, Mauri, Antonelli; Cutrone, André Silva