Italy bring in Andrea Conti and Davide Astori, but stick with the 4-2-4 formation against Israel, following their defeat to Spain.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on the LIVEBLOG.
The Azzurri need a boost after missing out on automatic World Cup qualification with their 3-0 loss in Madrid on Saturday night.
Italy bring in Andrea Conti and Davide Astori, but stick with the 4-2-4 formation against Israel, following their defeat to Spain.
It kicks off at 19.45 UK time (18.45 GMT), follow the build-up and action on the LIVEBLOG.
The Azzurri need a boost after missing out on automatic World Cup qualification with their 3-0 loss in Madrid on Saturday night.
Albania are just four points behind, so Giampiero Ventura cannot afford another slip-up, especially against an Israeli side in crisis.
Leonardo Bonucci is suspended and Leonardo Spinazzola injured, but the 4-2-4 system remains intact, bringing in Fiorentina captain Astori and Milan right-back Conti.
Davide Zappacosta is on the bench just days after his move from Torino to Chelsea.
Lorenzo Insigne, Andrea Belotti, Ciro Immobile and Antonio Candreva again form the front four, with Marco Verratti and Daniele De Rossi in support.
Israel suffered a shock 1-0 home defeat to Macedonia on Saturday, decided by Genoa’s Goran Pandev, and were jeered off the field.
This infuriated captain Eran Zahavi, who tore his armband off and threw it to the ground in frustration.
He was given a 12-month suspension by the Israeli FA for unsporting conduct and reacted by resigning from international duty.
Ben Bitton is out injured and striker Tomer Hemed was due to become the new captain, but he too is on the treatment table.
There are numerous changes to the expected XI, starting with goalkeeper Ariel Harush instead of Omri Glazer, but above all Tal Ben Chaim is benched, despite scoring back in September.
Israel have never beaten Italy, managing one draw and three losses, in which they scored three goals and conceded 13.
Their last encounter ended 3-1 in Haifa in September 2016.
These sides met only once on Italian soil, a 6-0 Italy victory in Turin on November 4, 1961, with Omar Sivori bagging four goals.
The referee is French official Benoit Bastien.
Italy: Buffon; Conti, Barzagli, Astori, Darmian; Verratti, De Rossi; Candreva, Belotti, Immobile, Insigne
Italy bench: Donnarumma, Perin, Rugani, Zappacosta, D’Ambrosio, Montolivo, Parolo, Pellegrini, Bernardeschi, El Shaarawy, Eder, Gabbiadini
Israel: Harush; Davidzada, Ben Haim, Tzedek, Keljtens; Cohen, Natcho, Kabha; Melikson, Refaelov; Shecter
Israel bench: Kleyman, Glazer, Benayoun, Danino, Elhamed, Solomon, Ben Chaim, Ohana, Einbinder