Inter give Dalbert his first start with Antonio Candreva, Joao Mario and Ivan Perisic supporting Mauro Icardi against Spal.
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The Nerazzurri have won both Serie A games so far this season and are seeking another victory to stay top of the Serie A table.
Luciano Spalletti is only missing Joao Cancelo and Davide Santon, but gives Dalbert his first start.
Roberto Gagliardini is given the nod in midfield with Borja Valero, while Candreva, Joao Mario and Perisic fan out behind hitman Icardi.
Transfer deadline day signing Yann Karamoh is on the bench for the first time.
Spal are still unbeaten in their first Serie A season for 49 years, having held Lazio to a 0-0 draw and beaten Udinese 3-2.
Alex Meret is still out of action, so Alfred Gomis again starts in goal, while Marios Oikonomou, Sergio Floccari and Luca Rizzo are also sidelined.
Veteran Marco Borriello is partnered by Alberto Paloschi, both of them former Milan strikers.
Spal have never won away to Inter, managing two draws and 14 defeats here.
Inter: Handanovic; D'Ambrosio, Skriniar, Miranda, Dalbert; Gagliardini, Borja Valero; Candreva, Joao Mario, Perisic; Icardi
Inter bench: Padelli, Berni, Ranocchia, Vanheusden, Nagatomo, Vecino, Brozovic, Karamoh, Eder, Pinamonti
Spal: Gomis; Salamon, Vicari, Vaisanen; Lazzari, Schiattarella, Viviani, Mora, Costa; Borriello, Paloschi
Spal bench: Marchegiani, Poluzzi, Felipe, Cremonesi, Della Giovanna, Mattiello, Grassi, Bellemo, Vitale, Schiavon, Konate, Antenucci, Bonazzoli
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