Diego Perotti and Gregoire Defrel are out of Roma’s trip to Milan, with Lorenzo Pellegrini and Hector Moreno in doubt.
It kicks off on Sunday at 17.00 UK time (16.00 GMT), click here for a match preview.
The Giallorossi must do without Perotti and Defrel, who sustained muscular problems while in Azerbaijan for the Champions League meeting with Qarabag.
Pellegrini is in doubt after coming down with flu symptoms, but is in the squad, along with Moreno, suffering from a slight knock.
Emerson Palmieri, Patrik Schick and Rick Karsdorp are long-term absentees.
Youth team striker Mirco Antonucci has been called up to bolster the ranks.
Roma squad for Milan: Alisson, Lobont, Skorupski; Juan Jesus, Kolarov, Moreno, Fazio, Peres, Manolas, Castan; Nainggolan, Strootman, Pellegrini, De Rossi, Gonalons, Florenzi, Gerson; Dzeko, Cengiz Under, Antonucci, El Shaarawy