Join us for all the build-up and action as it happens from the Champions League games, as Juventus host Barcelona and Roma visit Atletico Madrid.
They kick off at 19.45 GMT. If you are on a mobile device or tablet, then follow the Liveblog HERE.
The Bianconeri really need to prove themselves after a 3-0 defeat at Camp Nou in September and are fresh from a surprise 3-2 Serie A defeat to Sampdoria on Sunday.
Juventus will qualify for the next round if they win tonight, but a draw would be enough if Sporting fail to beat Olympiacos.
All eyes will be on Paulo Dybala, who hasn’t scored in the Champions League since facing Barcelona here in April.
Roma require only a point to be sure of going through to the knockout stages and could even lock down first place, despite being in the ‘group of death’ with Atletico Madrid, Chelsea and Qarabag.
Diego Simeone’s men haven’t won a game yet in Europe this season and are finding it difficult to adjust to their new massive Wanda Metropolitano Stadium.
Can the Giallorossi remain unbeaten and cause another upset on Spanish soil?
See the latest Serie A predictions and betting tips with Eurotips.co.uk