Lazio want to make it a perfect start in the Europa League as they host Vitesse with Luis Nani and Jordan Lukaku.
It kicks off at 18.00 GMT, you can follow the build-up and action from Lazio-Vitesse, Milan-Austria Vienna and Everton-Atalanta on the LIVEBLOG.
The Aquile have already qualified top of their group and are the only team to have won the opening four games in the group phase, but can keep their ambitions of a full house alive.
Simone Inzaghi rings the changes and needs a reaction after the Derby della Capitale defeat to Roma, which ended their run of nine consecutive victories in all competition.
Ciro Immobile, Lucas Leiva, Wallace, Felipe Anderson, Stefan Radu, Davide Di Gennaro and Felipe Caicedo are left in the stands.
Nani gets an opportunity to make his mark in support of striker Simone Palombi, while Lukaku, Patric, Luiz Felipe and Luca Crecco get rare starts.
Vitesse have defender Alexander Buttner suspended, along with injured Maikel van der Werff, Arnold Kruiswijk and Mohammed Osman.
Their star player is Tim Matavz in attack, but Luc Castaignos is sent to the bench.
The Dutch side will be out of the Europa League unless they conquer the Stadio Olimpico and the other game is a draw, because they’d then go head-to-head with Nice in the final round.
Lazio: Vargic; Patric, Luiz Felipe, Bastos; Basta, Murgia, Luis Alberto, Crecco, Lukaku; Nani; Palombi
Lazio bench: Strakosha, Guerriero, De Vrij, Lulic, Miceli, Marusic
Vitesse: Pasveer; Lelieveld, Kashia, Miazga, Faye; Serero, Ali, Mount, Foor; Rashica, Matavz, Linssen
Vitesse bench: Houwen, Dabo, Colkett, Bruns, Castaignos, Van Bergen, Oude Kotte
Ref: Ali Palabıyık (TUR)
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