Atalanta need a point at Goodison Park to be sure of Europa League qualification and look to Papu Gomez against Wayne Rooney’s Everton.
It kicks off at 20.05 GMT, follow the build-up and action from this game, Lazio-Vitesse and Milan-Austria Vienna on the LIVEBLOG.
The Orobici hadn’t been in Europe for 27 years, yet are on the verge of sealing their spot in the Round of 32 and are still unbeaten in the group.
They crushed Premier League outfit Everton 3-0 in Bergamo, but make the trip without injured Leonardo Spinazzola, while Mattia Caldara is not fully fit.
Papu Gomez leads the trident attack with Andrea Petagna and Bryan Cristante.
Everton have been in disastrous form this season, sacking Coach Ronald Koeman on October 23 and currently under caretaker manager David Unsworth.
Morgan Schneiderlin sits out a ban with injured Phil Jagielka, Seamus Coleman, Ross Barkley and Michael Keane injured, while James McCarthy is carrying a knock.
Rooney tries to bring some experience to the side, as Aaron Lennon and Gylfi Sigurdsson are not even on the bench.
There are approximately 3,500 Atalanta fans who have made the trip to Liverpool and, although there were some ugly clashes in the city centre late last night, local police confirmed they were not involved.
Everton: Robles; Kenny, Keane, Williams, Martina; Davies, Baningime, Klaasen; Mirallas, Rooney, Sandro
Everton bench: Pickford, Feeney, Gana Gueye, Besic, Vlasic, Lookman, Calvert-Lewin
Atalanta: Berisha; Toloi, Palomino, Masiello; Hateboer, Freuler, De Roon, Castagne; Cristante; Gomez, Petagna
Atalanta bench: Gollini, Gosens, Cornelius, Caldara, Kurtic, Mancini, Ilicic
Ref: Kehlet (DEN)