Gennaro Gattuso fields his first European Milan in a trip to Rijeka and bets on youth, including Andre Silva, Patrick Cutrone and Manuel Locatelli.
It kicks off at 18.00 GMT, follow the build-up and action from that game, Atalanta-Lyon and Zulte Waregem-Lazio on the LIVEBLOG.
The Rossoneri made their debut under new boss Gattuso in a shock 2-2 draw with bottom of the table Benevento on Sunday, as goalkeeper Alberto Brignoli nodded in the last-gasp equaliser.
That shattered an already nervous side that is very short on confidence, but the good news is that Milan are guaranteed top spot in the Europa League group regardless of what happens this evening.
Rijeka have nothing to play for either, as they will finish third and have so far lost both their home fixtures.
Gattuso leaves several big names behind, including Gianluigi Donnarumma, Franck Kessie, Suso, Jack Bonaventura and Ricardo Rodriguez.
Snubbed in Serie A, Andre Silva gets his chance in attack with teenage forward Cutrone, while Locatelli partners Lucas Biglia in midfield.
There’s also room for youth team player Niccolo Zanellato.
Rijeka are weakened by a ban for Josip Misic in midfield, while there was a doubt between Josip Elez and Roberto Puncec to partner Dario Zuparic in central defence.
When these sides met at San Siro in September, they squeezed past Rijeka 3-2, and are still unbeaten in Europe this season with seven wins and two draws, including the preliminary rounds.
Rijeka: Sluga; Vesovic, Elez, Zuparic, Zuta; Males, Pavicic; Acosty, Gavranovic, Krvzic; Puljic
Rijeka bench: Prskalo, Crnic, Lepinjica, Santek, Celikovic, Puncec, Mavrias
Milan: Storari; Zapata, Paletta, Romagnoli; Calabria, Zanellato, Biglia, Locatelli, Antonelli; Andre Silva, Cutrone
Milan bench: A Donnarumma, Abate, Bonucci, Musacchio, Gabbia, Montolivo, Forte
Ref: Vad (HUN)