Lazio give Jordan Lukaku and Felipe Caicedo rare starts and hope Felipe Anderson receives his first appearance of the season against Zulte Waregem.
It kicks off in Belgium at 20.05 GMT, follow the build-up and action on the LIVEBLOG.
The Aquile are already guaranteed first place in their group, having won five and drawn one.
With Luis Nani and Davide Di Gennaro injured, Ciro Immobile, Sergei Milinkovic-Savic and Stefan de Vrij among many stars rested, it’s a chance for Angelo Palombi and Caicedo.
It’s believed Felipe Anderson will finally get his first appearance of the season after a series of muscular problems.
Zulte Waregem are already eliminated and miss Derijck and Olayinka, but rotate their squad with Italian goalkeeper Nicola Leali on the bench.
Zulte Waregem: Bostyn; Heylen, De Fauw, Baudry; Walsh, Doumbia, Kaya, Madu; Coopman; De Pauw, Iseka
Zulte Waregem bench: Leali, De Sart, De Smet, Cordaro, Kastanos, Hamalainen, Saponjic
Lazio: Vargic; Patric, Luiz Felipe, Bastos; Basta, Miceli, Murgia, Crecco, Lukaku; Palombi, Caicedo
Lazio bench: Guerrieri, Armini, Wallace, Marusic, Leiva, Felipe Anderson
Ref: Kalogeropoulos (GRE)