Juventus surprisingly bench Paulo Dybala, Douglas Costa and Alex Sandro for the Derby d’Italia against full-strength leaders Inter.
There are so many layers to this showdown, as Inter are the Serie A leaders and the only team still unbeaten in Italy this season.
Juve sit in third place, having beaten previous leaders Napoli last week, and are targeting a record seventh straight Scudetto.
This is also the Derby d’Italia, one of the most bitter rivalries in Italian football, and sees Gonzalo Higuain and Mauro Icardi go head-to-head for the starting spot in the Argentina line-up.
Max Allegri has made some very surprising decisions for this clash, dropping off-form Dybala, Alex Sandro and Douglas Costa in favour of a 4-3-3 system with Mario Mandzukic and Juan Cuadrado flanking Higuain.
Kwadwo Asamoah celebrates his birthday with a starting spot, as Mattia De Sciglio takes the other flank.
Gigi Buffon, Stephan Lichtsteiner and Marko Pjaca are out injured, so Wojciech Szczesny takes the gloves.
Inter have been reticent to make many changes this season and some were forced upon them in the 5-0 victory over Chievo, but Roberto Gagliardini and Joao Miranda have completed their bans.
Matias Vecino also returns from injury, but Marcelo Brozovic keeps his place and sends Gagliardini to the bench, moving Borja Valero to a deeper role.
Antonio Candreva, Brozovic and Ivan Perisic support Capocannoniere Mauro Icardi, who has already put seven goals past Juventus in his career.
The last time the Nerazzurri defeated the Old Lady in Turin was in 2012 when a Diego Milito brace and a late Rodrigo Palacio goal ended Juve’s 49-games unbeaten run in Serie A and sealed a 3-1 victory for the visitors.
Juventus: Szczesny; De Sciglio, Benatia, Chiellini, Asamoah; Khedira, Pjanic, Matuidi; Cuadrado, Higuain, Mandzukic
Juventus bench: Pinsoglio, Loria, Barzagli, Rugani, Alex Sandro, Marchisio, Sturaro, Bentancur, Douglas Costa, Dybala, Bernardeschi
Inter: Handanovic; D’Ambrosio, Skriniar, Miranda, Santon; Vecino, Borja Valero; Candreva, Brozovic, Perisic; Icardi
Inter bench: Padelli, Berni, Ranocchia, Joao Cancelo, Nagatomo, Dalbert, Joao Mario, Gagliardini, Karamoh, Eder, Pinamonti