Roma give Patrik Schick his first start of the season, flanked by Gerson and Stephan El Shaarawy, in the tricky trip to Chievo.
It kicks off at the Bentegodi at 11.30 GMT, follow the build-up and action as it happens on the LIVEBLOG.
The Giallorossi are riding a wave of enthusiasm after winning their Champions League group and can close the gap on the Serie A leading pack.
Daniele De Rossi sits out a ban with Gregoire Defrel and Rick Karsdorp injured, but Edin Dzeko is given a well-earned and rare rest.
Instead, former Sampdoria striker Schick is given his first start in the Roma jersey and he’s taking the centre-forward role rather than on the wing.
He’s flanked by Gerson and El Shaarawy in what is clearly meant to be a rapid front three.
Maxime Gonalons steps in for De Rossi, while Juan Jesus allows Kostas Manolas a weekend on the bench.
Chievo go into this game desperate for a positive result after their 5-0 humiliation at the hands of Inter last week and their home form has been particularly poor recently.
Coach Rolando Maran must do without Lucas Castro, Perparim Hetemaj and Nicola Rigoni, but Ivan Radovanovic returns from suspension, so there is at least one member of the first-choice midfield.
Roberto Inglese is supported by Valter Birsa and Riccardo Meggiorini.
Chievo haven’t beaten Roma at their home ground since December 16, 2012. The 2012-2013 season also happened to be the last time the Flying Donkeys did a ‘double’ over the Giallorossi, defeating them 1-0 both home and away.
Chievo: Sorrentino; Cacciatore, Tomovic, Gamberini, Jaroszynski; Depaoli, Radovanovic, Bastien; Birsa; Meggiorini, Inglese
Chievo bench: Seculin, Confente, Cesar, Dainelli, Bani, Gobbi, Gaudino, Garritano, Pucciarelli, Stepinski, Leris, Pellissier
Roma: Alisson; Bruno Peres, Fazio, Juan Jesus, Kolarov; Nainggolan, Gonalons, Strootman; Gerson, Schick, El Shaarawy
Roma bench: Lobont, Skorupski, Moreno, Florenzi, Emerson, Manolas, Pellegrini, Dzeko, Under, Perotti