Gennaro Gattuso completely revamps his struggling Milan with a 4-3-3 formation against Roberto Donadoni’s impressive Bologna.
It kicks off at San Siro at 19.45 GMT, follow the build-up and action as it happens on the LIVEBLOG.
The Rossoneri are in crisis, as after firing Coach Vincenzo Montella, new boss Gattuso managed only a 2-2 draw with bottom of the table Benevento – their only point of the season – and a 2-0 Europa League defeat at Rijeka.
This is his first home game in charge and former midfielder Rino has decided to scrap the three-man defence in favour of a more traditional Milan 4-3-3 formation.
Alessio Romagnoli is suspended, with Lucas Biglia, Andrea Conti and Hakan Calhanoglu injured, so Franck Kessie, Riccardo Montolivo and Jack Bonaventura form the midfield.
Suso and Fabio Borini, the latter in a more advanced role than he has been used to recently, flank Nikola Kalinic, as Andre Silva is again benched.
Bologna have former Milan midfielder Andrea Poli suspended, plus Federico Di Francesco out for at least another month.
There are some familiar faces in the side, as Simone Verdi was in the Rossoneri youth academy and sold for a minimal fee, while Mattia Destro had a loan spell at San Siro.
Rodrigo Palacio called this arena home for many years when representing their arch-rivals Inter.
Bologna have lost five of their last seven league visits to Milan, aside from a 1-0 win and 1-1 draw.
The Rossoneri haven’t found the net on home turf in Serie A since November 20. Although it has been snowing in Milan for hours, the pitch has been protected with plastic sheets.
Milan: G Donnarumma; Abate, Musacchio, Bonucci, Rodriguez; Kessia, Montolivo, Bonaventura; Suso, Kalinic, Borini
Bologna: Mirante; Torosidis, Gonzalez, Helander, Masina; Donsah, Pulgar, Nagy; Verdi, Destro, Palacio
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