Roma start both Edin Dzeko and Patrik Schick in a new trident as they try to get back on track against unpredictable Cagliari.
It kicks off at 19.45 GMT, follow the build-up and action as it happens on the LIVEBLOG.
The Giallorossi have drawn two of their last three Serie A games, stalled by Genoa and Chievo, but Daniele De Rossi returns from his two-match ban for violent conduct.
This allows Kevin Strootman to rest, while Schick completes a new-look trident attack with Dzeko and Diego Perotti.
Gregoire Defrel and Rick Karsdorp remain on the treatment table.
Cagliari are certainly not dull, as they fought back from 2-0 down to hold Sampdoria 2-2 last week and were knocked out of the Coppa Italia by Serie C side Pordenone.
Their last victory was 1-0 away to Udinese on November 19, followed by two draws from four competitive matches.
Daniele Dessena and Paolo Faragò are out of action, with both goalkeepers Alessio Cragno and Rafael not fully fit.
Joao Pedro and Leonardo Pavoletti lead the attack with Gregory van der Wiel getting a rare start.
Roma: Alisson; Florenzi, Manolas, Fazio, Kolarov; Nainggolan, De Rossi, Pellegrini; Schick, Dzeko, Perotti
Cagliari: Cragno; Romagna, Pisacane, Andreolli; van der Wiel, Ionita, Cigarini, Barella, Padoin; Joao Pedro, Pavoletti