Duvan Zapata has made the trip to face his former club Napoli, but Sampdoria are without Karol Linetty and Ricky Alvarez.
It kicks off on Sunday at 14.00 GMT, click here for a match preview.
There were concerns the Colombia international would miss the game at the Stadio San Paolo after pulling up with a muscular problem.
However, Duvan Zapata recovered faster than expected and is in the squad to face his old club Napoli.
It is also a return for hometown forward Fabio Quagliarella.
Alvarez and Linetty are out of action for Coach Marco Giampaolo.
Sampdoria squad for Napoli: Puggioni, Tozzo, Viviano; Andersen, Bereszynski, Ferrari, Murru, Regini, Sala, Silvestre, Strinic; Barreto, Capezzi, Djuricic, Praet, Ramírez, Torreira, Verre; Caprari, Kownacki, Quagliarella, Duvan Zapata