Eusebio Di Francesco relies on Patrik Schick against his former club, but Sassuolo are without Domenico Berardi due to injury.
It kicks off at 14.00 GMT, follow the build-up and action from all today’s Serie A games on the LIVEBLOG.
Di Francesco has gone from strength to strength since taking over at the Stadio Olimpico, topping the Champions League group and securing a spot in the Coppa Italia Quarter-Final.
They are also fourth in Serie A with a game in hand, but have slowed down a little lately with just two wins in the last five rounds.
Gregoire Defrel is out injured against his old club, joined by Rick Karsdorp, but Schick gets the nod in attack with Edin Dzeko and Diego Perotti.
It’s a reunion for former Sassuolo midfielder Lorenzo Pellegrini too, while there are reports Berardi and Matteo Politano could be heading the other way in 2018.
The Neroverdi struggled at the start of the post-EDF era, but after sacking Cristian Bucchi to bring in Beppe Iachini, they have been a revelation.
Sassuolo have won three on the bounce, including a shock victory over Inter before Christmas.
Claud Adjapong, Stefano Sensi, Davide Biondini and Timo Letschert are on the treatment table, but the big news is that Berardi isn’t even on the bench after an injury in yesterday’s training session.
Antonino Ragusa steps into the trident attack with Diego Falcinelli and Politano.
There's a final run-out for Paolo Cannavaro, his last game before retiring to join brother Fabio in China.
They have a surprisingly good record at the Olimpico, drawing three of their previous four visits.
Roma: Alisson; Florenzi, Manolas, Fazio, Kolarov; Pellegrini, De Rossi, Nainggolan; Schick, Dzeko, Perotti
Sassuolo: Consigli; Lirola, Cannavaro, Acerbi, Peluso; Missiroli, Magnanelli, Duncan; Politano, Falcinelli, Ragusa