Inter need to stop the slide after three consecutive defeats and face a head-to-head for Europe with high-flying Lazio.
Luciano Spalletti’s men were the only unbeaten team in Italy up until a few weeks ago, but have since plummeted with defeats to Udinese, Sassuolo and a Coppa Italia exit to Milan on Wednesday night.
That tie went to extra time, decided by a Patrick Cutrone strike, and left the Nerazzurri demoralised after such a strong start to the season.
A victory here would take Lazio within a point of Inter in the Serie A standings – with a game in hand – while Roma are also piling on the pressure.
Joao Miranda and Danilo D’Ambrosio are still out injured, as Joao Cancelo and Davide Santon take the full-back roles, Andrea Ranocchia filling in for central defence.
It’s a special game for former Lazio winger Antonio Candreva, who partners Borja Valero, Ivan Perisic and Capocannoniere Mauro Icardi.
Lazio were also in the Coppa Italia midweek, but beat Fiorentina 1-0 on Tuesday to set up a Semi-Final against Milan.
Felipe Caicedo limped off with a muscular injury and will be out for a few weeks, but Ciro Immobile has shaken off flu symptoms to start with support from Luis Alberto and Sergej Milinkovic-Savic.
All eyes will be on Stefan de Vrij, as his contract expires in June and Inter are the favourites to sign the Dutch defender as a free agent.
Lazio have only won nine of their 74 Serie A trips to Inter, losing 41 and drawing 24. The most recent victory was 2-1 in December 2015.
Inter: Handanovic; Cancelo, Skriniar, Ranocchia, Santon; Vecino, Gagliardini; Candreva, Borja Valero, Perisic; Icardi
Inter bench: Padelli, Berni, Dalbert, Nagatomo, Joao Mario, Brozovic, Karamoh, Eder, Pinamonti
Lazio: Strakosha; Bastos, De Vrij, Radu; Marusic, Parolo, Leiva, Milinkovic-Savic, Lulic; Luis Alberto; Immobile
Lazio bench: Guerrieri, Vargic, Patric, Wallace, Basta, Luiz Felipe, Lukaku, Murgia, Jordao, Neto, Felipe Anderson, Nani