Napoli look to Adam Ounas, Jose Callejon, Marek Hamsik and Amadou Diawara in their Coppa Italia quarter-final against Atalanta.
It kicks off a the Stadio San Paolo at 19.45 GMT and the winner goes on to face Juventus or Torino in the semi-finals.
Maurizio Sarri’s men ended 2017 on a high, securing the status of Winter Champions in Serie A, one point ahead of Juve, but breaking away from the chasing pack.
Atalanta, on the other hand, saw out the year with a surprise home defeat to Cagliari, as they were wasteful in attack and conceded two early goals on the counter.
Sarri is usually reticent to rotate the squad, but this time brings in Luigi Sepe, Diawara, Zielinski and Ounas.
It remains to be seen whether Callejon or Ounas will take the centre-forward role, as Dries Mertens and Lorenzo Insigne are rested.
Atalanta rested Mattia Caldara in Serie A on Saturday, so he returns and is eager to add to his famous brace to win here 2-0 last season.
Bryan Cristante (also rested with Cagliari) and Papu Gomez are all present and correct, but Jasmin Kurtic is suspended for the Coppa.
These two sides have already met in Serie A, with Napoli emerging 3-1 winners on August 27.
However, last season Atalanta won here 2-0 with a brace from Caldara and were the only team to beat Napoli both home and away.
Perhaps the most famous clash was the Coppa Italia Final in June 1987, when Napoli won their second consecutive edition of the trophy.
There was only one Atalanta Coppa Italia victory in Naples and that was in 1973.
Napoli: Sepe; Hysaj, Chiriches, Koulibaly, Mario Rui; Rog, Diawara, Hamsik; Callejon, Ounas, Zielinski
Atalanta: Berisha; Toloi, Caldara, Palomino; Castagne, De Roon, Freuler, Gosens; Cristante; Cornelius, Gomez